Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau

The amyloid cascade hypothesis of Alzheimer’s disease (AD) positions tau protein as a downstream mediator of β-amyloid (Aβ) toxicity This is largely based on genetic cross breeding, which showed that tau ablation in young (3–7-month-old) transgenic mice overexpressing mutant amyloid precursor protei...

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Detalhes bibliográficos
Publicado no:Neurotherapeutics
Main Authors: Li, Xuling, Lei, Peng, Tuo, Qingzhang, Ayton, Scott, Li, Qiao-Xin, Moon, Steve, Volitakis, Irene, Liu, Rong, Masters, Colin L., Finkelstein, David I., Bush, Ashley I.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2015
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604188/
https://ncbi.nlm.nih.gov/pubmed/26260389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-015-0378-2
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