Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Proteolytic cleavage of the amyloid precursor protein (APP) into the Aβ peptide has been an extensively researched mechanism for Alzheimer’s disease, but the normal function of the protein is less understood. APP functions to regulate neuronal iron content by stabilizing the surface presentation of...

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Bibliografiset tiedot
Julkaisussa:Neurotherapeutics
Päätekijät: Belaidi, Abdel A., Gunn, Adam P., Wong, Bruce X., Ayton, Scott, Appukuttan, Ambili T., Roberts, Blaine R., Duce, James A., Bush, Ashley I.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Springer International Publishing 2018
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Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277293/
https://ncbi.nlm.nih.gov/pubmed/30112699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-018-0656-x
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