Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Proteolytic cleavage of the amyloid precursor protein (APP) into the Aβ peptide has been an extensively researched mechanism for Alzheimer’s disease, but the normal function of the protein is less understood. APP functions to regulate neuronal iron content by stabilizing the surface presentation of...

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Vydáno v:Neurotherapeutics
Hlavní autoři: Belaidi, Abdel A., Gunn, Adam P., Wong, Bruce X., Ayton, Scott, Appukuttan, Ambili T., Roberts, Blaine R., Duce, James A., Bush, Ashley I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer International Publishing 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277293/
https://ncbi.nlm.nih.gov/pubmed/30112699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-018-0656-x
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