Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice

Proteolytic cleavage of the amyloid precursor protein (APP) into the Aβ peptide has been an extensively researched mechanism for Alzheimer’s disease, but the normal function of the protein is less understood. APP functions to regulate neuronal iron content by stabilizing the surface presentation of...

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Detalhes bibliográficos
Publicado no:Neurotherapeutics
Main Authors: Belaidi, Abdel A., Gunn, Adam P., Wong, Bruce X., Ayton, Scott, Appukuttan, Ambili T., Roberts, Blaine R., Duce, James A., Bush, Ashley I.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6277293/
https://ncbi.nlm.nih.gov/pubmed/30112699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13311-018-0656-x
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