Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprotective roles. However, rare forms of familial Alzheimer’s disease are associated with mutations in APP that increase toxic amyloidogenic cleavage of APP and produce amylo...

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Vydáno v:Sci Rep
Hlavní autoři: Lopez Sanchez, M. Isabel G., Waugh, Hayley S., Tsatsanis, Andrew, Wong, Bruce X., Crowston, Jonathan G., Duce, James A., Trounce, Ian A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574989/
https://ncbi.nlm.nih.gov/pubmed/28852095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10233-0
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