Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta

Amyloid precursor protein (APP) and its extracellular domain, soluble APP alpha (sAPPα) play important physiological and neuroprotective roles. However, rare forms of familial Alzheimer’s disease are associated with mutations in APP that increase toxic amyloidogenic cleavage of APP and produce amylo...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Lopez Sanchez, M. Isabel G., Waugh, Hayley S., Tsatsanis, Andrew, Wong, Bruce X., Crowston, Jonathan G., Duce, James A., Trounce, Ian A.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2017
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5574989/
https://ncbi.nlm.nih.gov/pubmed/28852095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10233-0
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