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Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines
Synapse loss induced by amyloid beta (Aβ) is thought to be a primary contributor to cognitive decline in Alzheimer’s disease. Aβ is generated by proteolysis of amyloid precursor protein (APP), a synaptic receptor whose physiological function remains unclear. In the present study, we investigated the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900520/ https://ncbi.nlm.nih.gov/pubmed/20451588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2010.04.078 |
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