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Polo-like kinase 2 phosphorylation of amyloid precursor protein regulates activity-dependent amyloidogenic processing
Alzheimer’s disease (AD) is a neurodegenerative disorder with cognitive deficits. Amyloidogenic processing of amyloid precursor protein (APP) produces amyloid β (Aβ), the major component of hallmark AD plaques. Synaptic activity stimulates APP cleavage, whereas APP promotes excitatory synaptic trans...
Gorde:
| Argitaratua izan da: | Neuropharmacology |
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| Egile Nagusiak: | , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5414040/ https://ncbi.nlm.nih.gov/pubmed/28257888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.02.027 |
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