Inhibition of Polo-like kinase 2 ameliorates pathogenesis in Alzheimer’s disease model mice

Alzheimer disease (AD) is a neurodegenerative disorder characterized by pathological hallmarks of neurofibrillary tangles and amyloid plaques. The plaques are formed by aggregation and accumulation of amyloid β (Aβ), a cleavage fragment of amyloid precursor protein (APP). Enhanced neuronal activity...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lee, Ji Soo, Lee, Yeunkum, André, Emily A., Lee, Kea Joo, Nguyen, Thien, Feng, Yang, Jia, Nuo, Harris, Brent T., Burns, Mark P., Pak, Daniel T. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629081/
https://ncbi.nlm.nih.gov/pubmed/31306446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0219691
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