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A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments
We report the refinement of a high-throughput, liquid chromatography/mass spectrometry (LC/MS)–based screening method for the identification of covalent small-molecule binders to proteins. Using a custom library of 1600 disulfide-capped fragments targeting surface cysteine residues, we optimize samp...
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| 發表在: | SLAS Discov |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6609441/ https://ncbi.nlm.nih.gov/pubmed/28945980 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217732072 |
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