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Tethering in RNA: An RNA-Binding Fragment Discovery Tool

Tethering has been extensively used to study small molecule interactions with proteins through reversible disulfide bond forming reactions to cysteine residues. We describe the adaptation of Tethering to the study of small molecule binding to RNA using a thiol-containing adenosine analog (A(SH)). Am...

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Publicat a:Molecules
Autors principals: Tran, Kiet, Arkin, Michelle R., Beal, Peter A.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4760646/
https://ncbi.nlm.nih.gov/pubmed/25749683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules20034148
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