XLF and H2AX function in series to promote replication fork stability

XRCC4-like factor (XLF) is a non-homologous end joining (NHEJ) DNA double strand break repair protein. However, XLF deficiency leads to phenotypes in mice and humans that are not necessarily consistent with an isolated defect in NHEJ. Here we show that XLF functions during DNA replication. XLF under...

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Dettagli Bibliografici
Pubblicato in:J Cell Biol
Autori principali: Chen, Bo-Ruei, Quinet, Annabel, Byrum, Andrea K., Jackson, Jessica, Berti, Matteo, Thangavel, Saravanabhavan, Bredemeyer, Andrea L., Hindi, Issa, Mosammaparast, Nima, Tyler, Jessica K., Vindigni, Alessandro, Sleckman, Barry P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2019
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605786/
https://ncbi.nlm.nih.gov/pubmed/31123184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201808134
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