XLF and H2AX function in series to promote replication fork stability

XRCC4-like factor (XLF) is a non-homologous end joining (NHEJ) DNA double strand break repair protein. However, XLF deficiency leads to phenotypes in mice and humans that are not necessarily consistent with an isolated defect in NHEJ. Here we show that XLF functions during DNA replication. XLF under...

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Udgivet i:J Cell Biol
Main Authors: Chen, Bo-Ruei, Quinet, Annabel, Byrum, Andrea K., Jackson, Jessica, Berti, Matteo, Thangavel, Saravanabhavan, Bredemeyer, Andrea L., Hindi, Issa, Mosammaparast, Nima, Tyler, Jessica K., Vindigni, Alessandro, Sleckman, Barry P.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605786/
https://ncbi.nlm.nih.gov/pubmed/31123184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201808134
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