MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

The breast cancer susceptibility proteins BRCA1 and BRCA2 have emerged as key stabilizing factors for the maintenance of replication fork integrity following replication stress. In their absence, stalled replication forks are extensively degraded by the MRE11 nuclease, leading to chemotherapeutic se...

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Pubblicato in:Nat Commun
Autori principali: Lemaçon, Delphine, Jackson, Jessica, Quinet, Annabel, Brickner, Joshua R., Li, Shan, Yazinski, Stephanie, You, Zhongsheng, Ira, Grzegorz, Zou, Lee, Mosammaparast, Nima, Vindigni, Alessandro
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643552/
https://ncbi.nlm.nih.gov/pubmed/29038425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01180-5
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