MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

The breast cancer susceptibility proteins BRCA1 and BRCA2 have emerged as key stabilizing factors for the maintenance of replication fork integrity following replication stress. In their absence, stalled replication forks are extensively degraded by the MRE11 nuclease, leading to chemotherapeutic se...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Nat Commun
Prif Awduron: Lemaçon, Delphine, Jackson, Jessica, Quinet, Annabel, Brickner, Joshua R., Li, Shan, Yazinski, Stephanie, You, Zhongsheng, Ira, Grzegorz, Zou, Lee, Mosammaparast, Nima, Vindigni, Alessandro
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643552/
https://ncbi.nlm.nih.gov/pubmed/29038425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01180-5
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg