MUS81 nuclease activity is essential for replication stress tolerance and chromosome segregation in BRCA2-deficient cells

Failure to restart replication forks stalled at genomic regions that are difficult to replicate or contain endogenous DNA lesions is a hallmark of BRCA2 deficiency. The nucleolytic activity of MUS81 endonuclease is required for replication fork restart under replication stress elicited by exogenous...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Lai, Xianning, Broderick, Ronan, Bergoglio, Valérie, Zimmer, Jutta, Badie, Sophie, Niedzwiedz, Wojciech, Hoffmann, Jean-Sébastien, Tarsounas, Madalena
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5520020/
https://ncbi.nlm.nih.gov/pubmed/28714477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15983
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