Perturbing cohesin dynamics drives MRE11 nuclease-dependent replication fork slowing

Pds5 is required for sister chromatid cohesion, and somewhat paradoxically, to remove cohesin from chromosomes. We found that Pds5 plays a critical role during DNA replication that is distinct from its previously known functions. Loss of Pds5 hinders replication fork progression in unperturbed human...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Carvajal-Maldonado, Denisse, Byrum, Andrea K, Jackson, Jessica, Wessel, Sarah, Lemaçon, Delphine, Guitton-Sert, Laure, Quinet, Annabel, Tirman, Stephanie, Graziano, Simona, Masson, Jean-Yves, Cortez, David, Gonzalo, Susana, Mosammaparast, Nima, Vindigni, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6379725/
https://ncbi.nlm.nih.gov/pubmed/29917110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky519
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