PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

Acute treatment with replication-stalling chemotherapeutics causes reversal of replication forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss leads to chemosensitivity. Here, we show that fork degradation is no longer detectable in BRCA1-deficient cancer cells e...

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Udgivet i:Mol Cell
Main Authors: Quinet, Annabel, Tirman, Stephanie, Jackson, Jessica, Šviković, Saša, Lemaçon, Delphine, Carvajal-Maldonado, Denisse, González-Acosta, Daniel, Vessoni, Alexandre T., Cybulla, Emily, Wood, Matthew, Tavis, Steven, Batista, Luis F.Z., Méndez, Juan, Sale, Julian E., Vindigni, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007862/
https://ncbi.nlm.nih.gov/pubmed/31676232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.008
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