PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

Acute treatment with replication-stalling chemotherapeutics causes reversal of replication forks. BRCA proteins protect reversed forks from nucleolytic degradation, and their loss leads to chemosensitivity. Here, we show that fork degradation is no longer detectable in BRCA1-deficient cancer cells e...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Cell
Egile Nagusiak: Quinet, Annabel, Tirman, Stephanie, Jackson, Jessica, Šviković, Saša, Lemaçon, Delphine, Carvajal-Maldonado, Denisse, González-Acosta, Daniel, Vessoni, Alexandre T., Cybulla, Emily, Wood, Matthew, Tavis, Steven, Batista, Luis F.Z., Méndez, Juan, Sale, Julian E., Vindigni, Alessandro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cell Press 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7007862/
https://ncbi.nlm.nih.gov/pubmed/31676232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.10.008
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