MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

The breast cancer susceptibility proteins BRCA1 and BRCA2 have emerged as key stabilizing factors for the maintenance of replication fork integrity following replication stress. In their absence, stalled replication forks are extensively degraded by the MRE11 nuclease, leading to chemotherapeutic se...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Lemaçon, Delphine, Jackson, Jessica, Quinet, Annabel, Brickner, Joshua R., Li, Shan, Yazinski, Stephanie, You, Zhongsheng, Ira, Grzegorz, Zou, Lee, Mosammaparast, Nima, Vindigni, Alessandro
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2017
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5643552/
https://ncbi.nlm.nih.gov/pubmed/29038425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01180-5
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