Chargement en cours...
PCAF-mediated histone acetylation promotes replication fork degradation by MRE11 and EXO1 in BRCA-deficient cells
Stabilization of stalled replication forks is a prominent mechanism of PARP inhibitor (PARPi) resistance in BRCA-deficient tumors. Epigenetic mechanisms of replication fork stability are emerging but remain poorly understood. Here, we report the histone acetyltransferase PCAF as a fork-associated pr...
Enregistré dans:
| Publié dans: | Mol Cell |
|---|---|
| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2020
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7572766/ https://ncbi.nlm.nih.gov/pubmed/32966758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.08.018 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|