Double-Strand Break Repair Independent Role For BRCA2 In Blocking Stalled Replication Fork Degradation By MRE11

Breast cancer suppressor BRCA2 is critical for maintenance of genomic integrity and resistance to agents that damage DNA or collapse replication forks, presumably through homology-directed repair of double-strand breaks (HDR). Using single-molecule DNA fiber analysis, we show here that nascent repli...

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Huvudupphovsmän: Schlacher, Katharina, Christ, Nicole, Siaud, Nicolas, Egashira, Akinori, Wu, Hong, Jasin, Maria
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2011
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3261725/
https://ncbi.nlm.nih.gov/pubmed/21565612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2011.03.041
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