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Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA

Degradation and collapse of stalled replication forks are main sources of genomic instability, yet the molecular mechanisms for protecting forks from degradation/collapse are not well understood. Here, we report that human CST (CTC1‐STN1‐TEN1) proteins, which form a single‐stranded DNA‐binding compl...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Lyu, Xinxing, Lei, Kai‐Hang, Biak Sang, Pau, Shiva, Olga, Chastain, Megan, Chi, Peter, Chai, Weihang
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809791/
https://ncbi.nlm.nih.gov/pubmed/33210317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103654
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