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Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA

Degradation and collapse of stalled replication forks are main sources of genomic instability, yet the molecular mechanisms for protecting forks from degradation/collapse are not well understood. Here, we report that human CST (CTC1‐STN1‐TEN1) proteins, which form a single‐stranded DNA‐binding compl...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Lyu, Xinxing, Lei, Kai‐Hang, Biak Sang, Pau, Shiva, Olga, Chastain, Megan, Chi, Peter, Chai, Weihang
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7809791/
https://ncbi.nlm.nih.gov/pubmed/33210317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103654
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