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Human CST complex protects stalled replication forks by directly blocking MRE11 degradation of nascent‐strand DNA
Degradation and collapse of stalled replication forks are main sources of genomic instability, yet the molecular mechanisms for protecting forks from degradation/collapse are not well understood. Here, we report that human CST (CTC1‐STN1‐TEN1) proteins, which form a single‐stranded DNA‐binding compl...
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| Udgivet i: | EMBO J |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7809791/ https://ncbi.nlm.nih.gov/pubmed/33210317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019103654 |
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