Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes

Non-homologous end joining (NHEJ) is a major DNA double-strand break (DSB) repair pathway that functions in all phases of the cell cycle. NHEJ repairs genotoxic and physiological DSBs, such as those generated by ionizing radiation and during V(D)J recombination at antigen receptor loci, respectively...

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Опубликовано в: :Cell Cycle
Главные авторы: Hung, Putzer J., Chen, Bo-Ruei, George, Rosmy, Liberman, Caleb, Morales, Abigail J., Colon-Ortiz, Pedro, Tyler, Jessica K., Sleckman, Barry P., Bredemeyer, Andrea L.
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2016
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Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323033/
https://ncbi.nlm.nih.gov/pubmed/27830975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1253640
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