Deficiency of XLF and PAXX prevents DNA double-strand break repair by non-homologous end joining in lymphocytes

Non-homologous end joining (NHEJ) is a major DNA double-strand break (DSB) repair pathway that functions in all phases of the cell cycle. NHEJ repairs genotoxic and physiological DSBs, such as those generated by ionizing radiation and during V(D)J recombination at antigen receptor loci, respectively...

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Publié dans:Cell Cycle
Auteurs principaux: Hung, Putzer J., Chen, Bo-Ruei, George, Rosmy, Liberman, Caleb, Morales, Abigail J., Colon-Ortiz, Pedro, Tyler, Jessica K., Sleckman, Barry P., Bredemeyer, Andrea L.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5323033/
https://ncbi.nlm.nih.gov/pubmed/27830975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1253640
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