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PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice

Non-homologous end-joining (NHEJ) is the most prominent DNA double strand break (DSB) repair pathway in mammalian cells. PAXX is the newest NHEJ factor, which shares structural similarity with known NHEJ factors—XRCC4 and XLF. Here we report that PAXX is dispensable for physiological NHEJ in otherwi...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Liu, Xiangyu, Shao, Zhengping, Jiang, Wenxia, Lee, Brian J., Zha, Shan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216128/
https://ncbi.nlm.nih.gov/pubmed/28051062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13816
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