Ku recruits XLF to DNA double-strand breaks

XRCC4-like factor (XLF)—also known as Cernunnos—has recently been shown to be involved in non-homologous end-joining (NHEJ), which is the main pathway for the repair of DNA double-strand breaks (DSBs) in mammalian cells. XLF is likely to enhance NHEJ by stimulating XRCC4–ligase IV-mediated joining o...

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Hlavní autoři: Yano, Ken-ichi, Morotomi-Yano, Keiko, Wang, Shih-Ya, Uematsu, Naoya, Lee, Kyung-Jong, Asaithamby, Aroumougame, Weterings, Eric, Chen, David J
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2008
Témata:
Scientific Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2246615/
https://ncbi.nlm.nih.gov/pubmed/18064046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7401137
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