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Functional significance of the interaction with Ku in DNA double-strand break recognition of XLF

Ku heterodimer is essential for the repair of DNA double-strand breaks (DSBs) by non-homologous end-joining (NHEJ). Ku recruits XLF, also known as Cernunnos, to DSBs. Here we report domain analyses of Ku-XLF interaction. The heterodimeric domain of Ku was found to be sufficient for the recruitment o...

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Detaylı Bibliyografya
Asıl Yazarlar: Yano, Ken-ichi, Morotomi-Yano, Keiko, Lee, Kyung-Jong, Chen, David J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066473/
https://ncbi.nlm.nih.gov/pubmed/21349273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2011.02.020
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