High-Throughput Screening Approach for Identifying Compounds that Inhibit Non-Homologous End Joining

DNA double strand breaks (DSBs) are repaired primarily by homologous recombination (HR) or non-homologous end joining (NHEJ). Compounds that modulate HR have shown promise as cancer therapeutics. The V(D)J recombination reaction, which assembles antigen receptor genes in lymphocytes, is initiated by...

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Библиографические подробности
Опубликовано в: :SLAS Discov
Главные авторы: Bredemeyer, Andrea, Edwards, Bruce S., Haynes, Mark K., Morales, Abigail J., Wang, Yinan, Ursu, Oleg, Waller, Anna, Sklar, Larry A., Sleckman, Barry P.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997544/
https://ncbi.nlm.nih.gov/pubmed/29232168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217746324
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