High-Throughput Screening Approach for Identifying Compounds that Inhibit Non-Homologous End Joining

DNA double strand breaks (DSBs) are repaired primarily by homologous recombination (HR) or non-homologous end joining (NHEJ). Compounds that modulate HR have shown promise as cancer therapeutics. The V(D)J recombination reaction, which assembles antigen receptor genes in lymphocytes, is initiated by...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:SLAS Discov
Egile Nagusiak: Bredemeyer, Andrea, Edwards, Bruce S., Haynes, Mark K., Morales, Abigail J., Wang, Yinan, Ursu, Oleg, Waller, Anna, Sklar, Larry A., Sleckman, Barry P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997544/
https://ncbi.nlm.nih.gov/pubmed/29232168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555217746324
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