MRI is a DNA Damage Response Adaptor during Classical Non-Homologous End Joining

The modulator of retrovirus infection (MRI or CYREN) is a 30 kDa protein with a conserved N-terminal Ku-binding motif (KBM) and a C-terminal XLF-like motif (XLM). We show that MRI is intrinsically disordered and interacts with many DNA damage response (DDR) proteins, including the kinases ATM and DN...

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Publicat a:Mol Cell
Autors principals: Hung, Putzer J., Johnson, Britney, Chen, Bo-Ruei, Byrum, Andrea K., Bredemeyer, Andrea L., Yewdell, William T., Johnson, Tanya E., Lee, Brian J., Deivasigamani, Shruthi, Hindi, Issa, Amatya, Parmeshwar, Gross, Michael L., Paull, Tanya T., Pisapia, David J., Chaudhuri, Jayanta, Petrini, John J. H., Mosammaparast, Nima, Amarasinghe, Gaya K., Zha, Shan, Tyler, Jessica K., Sleckman, Barry P.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6083883/
https://ncbi.nlm.nih.gov/pubmed/30017584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.06.018
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