KAP-1 Promotes Resection of Broken DNA Ends Not Protected by γ-H2AX and 53BP1 in G(1)-Phase Lymphocytes

The resection of broken DNA ends is required for DNA double-strand break (DSB) repair by homologous recombination (HR) but can inhibit normal repair by nonhomologous end joining (NHEJ), the main DSB repair pathway in G(1)-phase cells. Antigen receptor gene assembly proceeds through DNA DSB intermedi...

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Main Authors: Tubbs, Anthony T., Dorsett, Yair, Chan, Elizabeth, Helmink, Beth, Lee, Baeck-Seung, Hung, Putzer, George, Rosmy, Bredemeyer, Andrea L., Mittal, Anuradha, Pappu, Rohit V., Chowdhury, Dipanjan, Mosammaparast, Nima, Krangel, Michael S., Sleckman, Barry P.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135573/
https://ncbi.nlm.nih.gov/pubmed/24842905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00441-14
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