Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination

The H2AX core histone variant is phosphorylated in chromatin around DNA double strand breaks (DSBs) and functions through unknown mechanisms to suppress antigen receptor locus translocations during V(D)J recombination. Formation of chromosomal coding joins and suppression of translocations involves...

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Main Authors: Yin, Bu, Savic, Velibor, Juntilla, Marisa M., Bredemeyer, Andrea L., Yang-Iott, Katherine S., Helmink, Beth A., Koretzky, Gary A., Sleckman, Barry P., Bassing, Craig H.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806628/
https://ncbi.nlm.nih.gov/pubmed/19887394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091320
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