Formation of Dynamic γ-H2AX Domains along Broken DNA Strands is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

A hallmark of the cellular response to DNA double strand breaks (DSBs) is histone H2AX phosphorylation in chromatin to generate γ-H2AX. Here, we demonstrate that γ-H2AX densities increase transiently along DNA strands as they are broken and repaired in G1 phase cells. The region across which γ-H2AX...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Glavni autori: Savic, Velibor, Yin, Bu, Maas, Nancy L., Bredemeyer, Andrea L., Carpenter, Andrea C., Helmink, Beth A., Yang-Iott, Katherine S., Sleckman, Barry P., Bassing, Craig H.
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744111/
https://ncbi.nlm.nih.gov/pubmed/19450528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.04.012
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items