Formation of Dynamic γ-H2AX Domains along Broken DNA Strands is Distinctly Regulated by ATM and MDC1 and Dependent upon H2AX Densities in Chromatin

A hallmark of the cellular response to DNA double strand breaks (DSBs) is histone H2AX phosphorylation in chromatin to generate γ-H2AX. Here, we demonstrate that γ-H2AX densities increase transiently along DNA strands as they are broken and repaired in G1 phase cells. The region across which γ-H2AX...

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Библиографические подробности
Главные авторы: Savic, Velibor, Yin, Bu, Maas, Nancy L., Bredemeyer, Andrea L., Carpenter, Andrea C., Helmink, Beth A., Yang-Iott, Katherine S., Sleckman, Barry P., Bassing, Craig H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2009
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744111/
https://ncbi.nlm.nih.gov/pubmed/19450528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.04.012
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