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Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma
H2AX and Artemis each cooperate with p53 to suppress lymphoma. Germline H2ax(−/−)p53(−/−) mice die of T-cell receptor-β(−) (TCR-β(−)) thymic lymphomas with translocations and other lesions characteristic of human T-cell acute lymphoblastic leukemia. Here, we demonstrate that mice with inactivation o...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3037742/ https://ncbi.nlm.nih.gov/pubmed/20947684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-273045 |
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