Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas

T-cell acute lymphoblastic lymphomas commonly demonstrate activating Notch1 mutations as well as mutations or deletions in Fbxw7. However, because Fbxw7 targets Notch1 for degradation, genetic alterations in these genes are expected to be mutually exclusive events in lymphomagenesis. Previously, by...

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Main Authors: Jen, Kuang-Yu, Song, Ihn Young, Banta, Karl Luke, Wu, Di, Mao, Jian-Hua, Balmain, Allan
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2012
Teme:
Lymphoid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3265203/
https://ncbi.nlm.nih.gov/pubmed/22117044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-327619
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