Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas

Peripheral T-cell lymphomas (PTCLs) are aggressive malignancies of mature T lymphocytes with 5-year overall survival rates of only ∼ 35%. Improvement in outcomes has been stymied by poor understanding of the genetics and molecular pathogenesis of PTCL, with a resulting paucity of molecular targets f...

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Bibliographic Details
Published in:Blood
Main Authors: Vasmatzis, George, Johnson, Sarah H., Knudson, Ryan A., Ketterling, Rhett P., Braggio, Esteban, Fonseca, Rafael, Viswanatha, David S., Law, Mark E., Kip, N. Sertac, Özsan, Nazan, Grebe, Stefan K., Frederick, Lori A., Eckloff, Bruce W., Thompson, E. Aubrey, Kadin, Marshall E., Milosevic, Dragana, Porcher, Julie C., Asmann, Yan W., Smith, David I., Kovtun, Irina V., Ansell, Stephen M., Dogan, Ahmet, Feldman, Andrew L.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Lymphoid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5070713/
https://ncbi.nlm.nih.gov/pubmed/22855598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-03-419937
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