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Sequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas
T-cell acute lymphoblastic lymphomas commonly demonstrate activating Notch1 mutations as well as mutations or deletions in Fbxw7. However, because Fbxw7 targets Notch1 for degradation, genetic alterations in these genes are expected to be mutually exclusive events in lymphomagenesis. Previously, by...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society of Hematology
2012
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3265203/ https://ncbi.nlm.nih.gov/pubmed/22117044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-01-327619 |
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