Subclonal TP53 copy number is associated with prognosis in multiple myeloma

Multiple myeloma (MM) is a genetically heterogeneous cancer of bone marrow plasma cells with variable outcome. To assess the prognostic relevance of clonal heterogeneity of TP53 copy number, we profiled tumors from 1777 newly diagnosed Myeloma XI trial patients with multiplex ligation-dependent prob...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Shah, Vallari, Johnson, David C., Sherborne, Amy L., Ellis, Sidra, Aldridge, Frances M., Howard-Reeves, Julie, Begum, Farzana, Price, Amy, Kendall, Jack, Chiecchio, Laura, Savola, Suvi, Jenner, Matthew W., Drayson, Mark T., Owen, Roger G., Gregory, Walter M., Morgan, Gareth J., Davies, Faith E., Houlston, Richard S., Cook, Gordon, Cairns, David A., Jackson, Graham, Kaiser, Martin F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533595/
https://ncbi.nlm.nih.gov/pubmed/30373884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-06-857250
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