Subclonal TP53 copy number is associated with prognosis in multiple myeloma

Multiple myeloma (MM) is a genetically heterogeneous cancer of bone marrow plasma cells with variable outcome. To assess the prognostic relevance of clonal heterogeneity of TP53 copy number, we profiled tumors from 1777 newly diagnosed Myeloma XI trial patients with multiplex ligation-dependent prob...

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Bibliografske podrobnosti
izdano v:Blood
Main Authors: Shah, Vallari, Johnson, David C., Sherborne, Amy L., Ellis, Sidra, Aldridge, Frances M., Howard-Reeves, Julie, Begum, Farzana, Price, Amy, Kendall, Jack, Chiecchio, Laura, Savola, Suvi, Jenner, Matthew W., Drayson, Mark T., Owen, Roger G., Gregory, Walter M., Morgan, Gareth J., Davies, Faith E., Houlston, Richard S., Cook, Gordon, Cairns, David A., Jackson, Graham, Kaiser, Martin F.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2018
Teme:
Lymphoid Neoplasia
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6533595/
https://ncbi.nlm.nih.gov/pubmed/30373884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2018-06-857250
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