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The Response to and Repair of RAG-Mediated DNA Double Stranded Breaks

Developing lymphocytes must assemble antigen receptor genes encoding the B cell and T cell receptors. This process is executed by the V(D)J recombination reaction, which can be divided into DNA cleavage and DNA joining steps. The former is carried out by a lymphocyte-specific RAG endonuclease, which...

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Autori principali: Helmink, Beth A., Sleckman, Barry P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4038028/
https://ncbi.nlm.nih.gov/pubmed/22224778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-immunol-030409-101320
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