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The Response to and Repair of RAG-Mediated DNA Double Stranded Breaks
Developing lymphocytes must assemble antigen receptor genes encoding the B cell and T cell receptors. This process is executed by the V(D)J recombination reaction, which can be divided into DNA cleavage and DNA joining steps. The former is carried out by a lymphocyte-specific RAG endonuclease, which...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4038028/ https://ncbi.nlm.nih.gov/pubmed/22224778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-immunol-030409-101320 |
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