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RAG-induced DNA double-strand breaks signal through Pim2 to promote pre–B cell survival and limit proliferation
Interleukin 7 (IL-7) promotes pre–B cell survival and proliferation by activating the Pim1 and Akt kinases. These signals must be attenuated to induce G1 cell cycle arrest and expression of the RAG endonuclease, which are both required for IgL chain gene rearrangement. As lost IL-7 signals would lim...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3260864/ https://ncbi.nlm.nih.gov/pubmed/22201128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20112078 |
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