RAG-mediated DNA double-strand breaks activate a cell type–specific checkpoint to inhibit pre–B cell receptor signals

DNA double-strand breaks (DSBs) activate a canonical DNA damage response, including highly conserved cell cycle checkpoint pathways that prevent cells with DSBs from progressing through the cell cycle. In developing B cells, pre–B cell receptor (pre–BCR) signals initiate immunoglobulin light (Igl) c...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Bednarski, Jeffrey J., Pandey, Ruchi, Schulte, Emily, White, Lynn S., Chen, Bo-Ruei, Sandoval, Gabriel J., Kohyama, Masako, Haldar, Malay, Nickless, Andrew, Trott, Amanda, Cheng, Genhong, Murphy, Kenneth M., Bassing, Craig H., Payton, Jacqueline E., Sleckman, Barry P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4749927/
https://ncbi.nlm.nih.gov/pubmed/26834154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151048
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