Histone H2AX stabilizes broken DNA strands to suppress chromosome breaks and translocations during V(D)J recombination

The H2AX core histone variant is phosphorylated in chromatin around DNA double strand breaks (DSBs) and functions through unknown mechanisms to suppress antigen receptor locus translocations during V(D)J recombination. Formation of chromosomal coding joins and suppression of translocations involves...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yin, Bu, Savic, Velibor, Juntilla, Marisa M., Bredemeyer, Andrea L., Yang-Iott, Katherine S., Helmink, Beth A., Koretzky, Gary A., Sleckman, Barry P., Bassing, Craig H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2009
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806628/
https://ncbi.nlm.nih.gov/pubmed/19887394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091320
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