DNA2 drives processing and restart of reversed replication forks in human cells

Accurate processing of stalled or damaged DNA replication forks is paramount to genomic integrity and recent work points to replication fork reversal and restart as a central mechanism to ensuring high-fidelity DNA replication. Here, we identify a novel DNA2- and WRN-dependent mechanism of reversed...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Thangavel, Saravanabhavan, Berti, Matteo, Levikova, Maryna, Pinto, Cosimo, Gomathinayagam, Shivasankari, Vujanovic, Marko, Zellweger, Ralph, Moore, Hayley, Lee, Eu Han, Hendrickson, Eric A., Cejka, Petr, Stewart, Sheila, Lopes, Massimo, Vindigni, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347643/
https://ncbi.nlm.nih.gov/pubmed/25733713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201406100
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