β-Secretase BACE1 Regulates Hippocampal and Reconstituted M-Currents in a β-Subunit-Like Fashion

The β-secretase BACE1 is widely known for its pivotal role in the amyloidogenic pathway leading to Alzheimer's disease, but how its action on transmembrane proteins other than the amyloid precursor protein affects the nervous system is only beginning to be understood. We report here that BACE1...

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Publié dans:J Neurosci
Auteurs principaux: Hessler, Sabine, Zheng, Fang, Hartmann, Stephanie, Rittger, Andrea, Lehnert, Sandra, Völkel, Meike, Nissen, Matthias, Edelmann, Elke, Saftig, Paul, Schwake, Michael, Huth, Tobias, Alzheimer, Christian
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6605557/
https://ncbi.nlm.nih.gov/pubmed/25716831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3127-14.2015
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