β-Secretase BACE1 Is Required for Normal Cochlear Function

Cleavage of amyloid precursor protein (APP) by β-secretase BACE1 initiates the production and accumulation of neurotoxic amyloid-β peptides, which is widely considered an essential pathogenic mechanism in Alzheimer's disease (AD). Here, we report that BACE1 is essential for normal auditory func...

詳細記述

保存先:
書誌詳細
出版年:J Neurosci
主要な著者: Dierich, Marlen, Hartmann, Stephanie, Dietrich, Nadine, Moeser, Philip, Brede, Franziska, Johnson Chacko, Lejo, Tziridis, Konstantin, Schilling, Achim, Krauss, Patrick, Hessler, Sabine, Karch, Sandra, Schrott-Fischer, Anneliese, Blumer, Michael, Birchmeier, Carmen, Oliver, Dominik, Moser, Tobias, Schulze, Holger, Alzheimer, Christian, Leitner, Michael G., Huth, Tobias
フォーマット: Artigo
言語:Inglês
出版事項: Society for Neuroscience 2019
主題:
Research Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6832675/
https://ncbi.nlm.nih.gov/pubmed/31527119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0028-19.2019
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料