Ion channel regulation by β-secretase BACE1 – enzymatic and non-enzymatic effects beyond Alzheimer's disease

β-site APP-cleaving enzyme 1 (BACE1) has become infamous for its pivotal role in the pathogenesis of Alzheimer's disease (AD). Consequently, BACE1 represents a prime target in drug development. Despite its detrimental involvement in AD, it should be quite obvious that BACE1 is not primarily pre...

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Bibliographic Details
Published in:Channels (Austin)
Main Authors: Lehnert, Sandra, Hartmann, Stephanie, Hessler, Sabine, Adelsberger, Helmuth, Huth, Tobias, Alzheimer, Christian
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001140/
https://ncbi.nlm.nih.gov/pubmed/27253079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336950.2016.1196307
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