Preferential Inhibition of Tonically over Phasically Activated NMDA Receptors by Pregnane Derivatives

Postsynaptic N-methyl-d-aspartate receptors (NMDARs) phasically activated by presynaptically released glutamate are critical for synaptic transmission and plasticity. However, under pathological conditions, excessive activation of NMDARs by tonically increased ambient glutamate contributes to excito...

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Pubblicato in:J Neurosci
Autori principali: Vyklicky, Vojtech, Smejkalova, Tereza, Krausova, Barbora, Balik, Ales, Korinek, Miloslav, Borovska, Jirina, Horak, Martin, Chvojkova, Marketa, Kleteckova, Lenka, Vales, Karel, Cerny, Jiri, Nekardova, Michaela, Chodounska, Hana, Kudova, Eva, Vyklicky, Ladislav
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2016
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6602038/
https://ncbi.nlm.nih.gov/pubmed/26888927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3181-15.2016
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