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Location is the key to function: HMGB1 in sepsis and trauma-induced inflammation
HMGB1 is a multifunctional nuclear protein, probably known best as a prototypical alarmin or damage-associated molecular pattern (DAMP) molecule when released from cells. However, HMGB1 has multiple functions that depend on its location in the nucleus, in the cytosol, or extracellularly after either...
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| Udgivet i: | J Leukoc Biol |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6597316/ https://ncbi.nlm.nih.gov/pubmed/30946496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.3MIR1218-497R |
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