Platelet HMGB1 is required for efficient bacterial clearance in intra-abdominal bacterial sepsis in mice

Thrombocytopenia impairs host defense and hemostasis in sepsis. However, the mechanisms of how platelets regulate host defense are not fully understood. High-mobility group box 1 (HMGB1), a danger-associated molecular pattern protein, is released during infection and contributes to the pathogenesis...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Zhou, Hui, Deng, Meihong, Liu, Yingjie, Yang, Chenxuan, Hoffman, Rosemary, Zhou, Jingjiao, Loughran, Patricia A., Scott, Melanie J., Neal, Matthew D., Billiar, Timothy R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Platelets and Thrombopoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5873229/
https://ncbi.nlm.nih.gov/pubmed/29563120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017011817
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